© 2003 European Society of Cardiology
Congestive heart failure with preserved left ventricular systolic function after acute myocardial infarction: clinical and prognostic implications
a Department of Cardiology, Odense University Hospital Odense, Denmark
b Department of Cardiology, Gentofte Univerity Hospital Denmark
c Department of Cardiology Rigshospitalet, Copenhagen, Denmark
d Department of Medicine, Svendborg Hospital Denmark
e Department of Cardiology, Skejby University Hospital Denmark
* Corresponding author. Tel.: +45-6611-3333 E-mail address: jem{at}dadlnet.dk
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Abstract |
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Aims: To characterise the prevalence, in-hospital complications, management, and long-term outcome of patients with congestive heart failure but preserved left ventricular systolic function after acute myocardial infarction.
Methods: 3166 consecutive patients screened for entry in the Bucindolol Evaluation in Acute Myocardial Infarction Trial with definite acute myocardial infarction and echocardiographic assessment of left ventricular systolic function were included between 1998 and 1999 in this prospective observational study. Main outcome measures were occurrences of in-hospital complications and all cause mortality.
Results: Congestive heart failure was seen during hospitalisation in 1464 patients (46%), 717 patients had preserved left ventricular systolic function (wall motion index 
1.3 corresponding to ejection fraction 0.40), and 732 patients had systolic dysfunction (wall motion index <1.3). One year mortality in patients with no heart failure, heart failure with preserved systolic function, and heart failure with systolic dysfunction were 6, 22 and 35%, P<0.0001. Unadjusted risk of death from all causes associated with heart failure and preserved systolic function was 3.3 (95% CI 2.8–4.0), and after adjustment for baseline characteristics and left ventricular systolic function in multivariate Cox proportional hazards analysis the risk was 2.1 (95% CI 1.7–2.6), P<0.0001.
Conclusions: Congestive heart failure is frequently present in patients with preserved left ventricular systolic function, and is associated with increased risk of in-hospital complications and death following acute myocardial infarction.
Key Words: Left ventricular systolic function • Acute myocardial infarction • Congestive heart failure
Received March 5, 2003; Revised April 24, 2003; Accepted July 17, 2003
This article is for the Bucindolol Evaluation in Acute Myocardial Infarction Trial Group.
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