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European Journal of Heart Failure 2003 5(4):575-578; doi:10.1016/S1388-9842(03)00036-9
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© 2003 European Society of Cardiology

Acute cardiac failure in neuroleptic malignant syndrome*

Patrick Sparrowa,*, Dermot Murnaghanb, Peter Kearneya, John Hoganc and Mary N. Sheppardd

a Department of Cardiology Cork University Hospital, Cork, Ireland
b Department of Medicine Cork University Hospital, Cork, Ireland
c Department of Pathology Cork University Hospital, Cork, Ireland
d Department of Pathology Royal Brompton Hospital, London, UK

* Corresponding author. Present address: BHF Cardiac MRI Unit, B Floor Clarendon Wing, Leeds General Infirmary, Great George Street, Leeds LS1 3EX, UK. Tel.: +44-113-392-5617; fax: +44-113-392-3775 E-mail address: patsparrow{at}doctors.net.uk


  Abstract

We present a case of rapid onset acute cardiac failure developing as part of Neuroleptic malignant syndrome in a 35-year-old woman following treatment with Thioridazine and Lithium. Post mortem histology of cardiac and skeletal muscle showed similar changes of focal cellular necrosis and vacuolation suggesting a common disease process.

Key Words: Acute cardiac failure • Neuroleptic malignant syndrome • Myocyte necrosis • Vacuolation

Received October 4, 2002; Revised December 12, 2002; Accepted January 23, 2003

* No support grants were received in the writing of this paper.


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