© 2002 European Society of Cardiology
Effect of nebivolol on left ventricular function in patients with chronic heart failure: a pilot study
Medizinische Klinik III, Otfried-Müllerstr. 10, 72076 Tübingen, Germany
* Corresponding author. Tel.: +49-7071-2982711; fax: +49-7071-360245. E-mail address: bernhard.brehm{at}onlinehome.de
 |
Abstract |
|---|
Background: Sympathetic activity is a significant predictor of a poor prognosis in heart failure. Beta-blockers have been shown to improve the prognosis of patients with heart failure.
Aim: This pilot study examined the tolerability and efficacy of the new β-blocker nebivolol on left ventricular function in patients with chronic heart failure.
Methods and Results: Twelve patients with an ejection fraction of 13–39% were included in this double blind, placebo-controlled randomized trial of nebivolol administered in addition to standard therapy. Exercise time, heart rate, left ventricular function and tolerability were examined at baseline and after 3 months of orally administered nebivolol (2.5 and 5 mg, n=6) or placebo (n=6). Nebivolol was well tolerated and the NYHA class improved in four patients. Heart rate decreased while the maximal exercise duration and performance remained stable. Left ventricular function increased (ejection fraction 31.5±10.11 to 42.0±10.99%, P
0.01) after 12 weeks of nebivolol. The left ventricular end-systolic diameter decreased in the nebivolol-group from 56.5±9.40 to 50.2±9.43 mm (P0.02).
Conclusion: These data indicate that nebivolol might improve cardiac function in patients with reduced left ventricular function.
Key Words: β-Blocker • Chronic heart failure • Left ventricular function
Received December 17, 2001; Revised March 19, 2002; Accepted May 21, 2002
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  J. Abdulla, L. Kober, E. Christensen, and C. Torp-Pedersen Effect of beta-blocker therapy on functional status in patients with heart failure -- A meta-analysis Eur J Heart Fail, August 1, 2006; 8(5): 522 - 531. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Edes, Z. Gasior, and K. Wita Effects of nebivolol on left ventricular function in elderly patients with chronic heart failure: results of the ENECA study Eur J Heart Fail, June 1, 2005; 7(4): 631 - 639. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. G.F. Cleland, P. H. Loh, N. Freemantle, A. L. Clark, and A. P. Coletta Clinical trials update from the European Society of Cardiology: SENIORS, ACES, PROVE-IT, ACTION, and the HF-ACTION trial Eur J Heart Fail, October 1, 2004; 6(6): 787 - 791. [Abstract] [Full Text] [PDF]
|
|