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European Journal of Heart Failure 2002 4(6):687-697; doi:10.1016/S1388-9842(02)00169-1
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© 2002 European Society of Cardiology

Analysis of altered genomic expression profiles in the senescent and diseased myocardium using cDNA microarrays

Ondrej Juhasz, Yi Zhu, Rahul Garg, Sergey V. Anisimov and Kenneth R. Boheler*

Laboratory of Cardiovascular Science, Gerontology Research Center, National Institute on Aging, National Institutes of Health 5600 Nathan Shock Drive, Baltimore, MD 21224, USA

* Corresponding author. Tel.: +1-410-558-8095; fax: +1-410-558-8150. E-mail address: bohelerk{at}grc.nia.nih.gov


  Abstract

Cardiac function deteriorates with aging or disease. Short term, any changes in heart function may be beneficial, but long term the alterations are often detrimental. At a molecular level, functional adaptations involve quantitative and qualitative changes in gene expression. Analysis of all the RNA transcripts present in a cell's population (transcriptome) offers unprecedented opportunities to map these transitions. Microarrays (chips), capable of evaluating thousands of transcripts in one assay, are ideal for transcriptome analyses. Gene expression profiling provides information about the dynamics of total genome expression in response to environmental changes and may point to candidate genes responsible for the cascade of events that result in disease or are a consequence of aging. The aim of this review is to describe how comparisons of cellular transcriptomes by cDNA array based techniques provide information about the dynamics of total gene expression, and how the results can be applied to the study of cardiovascular disease and aging.

Key Words: Cardiovascular • Heart • Disease • Aging • Microarrays • Chips • Genomics

Received September 28, 2001; Revised February 21, 2002; Accepted May 1, 2002


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