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European Journal of Heart Failure 2002 4(4):431-438; doi:10.1016/S1388-9842(02)00024-7
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© 2002 European Society of Cardiology

[123I]-phenylpentadecanoic acid uptake in patients with dilated cardiomyopathy

Eckart Michea,*, Andrea Radzewitza, Gunawan Notohamiprodjob, Detlev Ballerc, Axel Kloppec, Siegfried Eckertc and Ulrich Gleichmannc

a Herz-Kreislauf-Zentrum Gernsbach/Schwarzwald 76593 Gernsbach, Germany
b Institut für molekulare Biophysik, Radiopharmazie und Nuklearmedizin Germany
c Kardiologische Klinik, Herz- und Diabeteszentrum Nordrhein-Westfalen, Klinik der Ruhr-Universität Bochum 32545 Bad Oeynhausen, Germany

* Corresponding author. Tel.: +49-7224-9920; fax: +49-7224-992-444 E-mail address: cardiol{at}hkz-gernsbach.de


  Abstract

Background: The rate constant for global fatty acid influx (k1) was studied in 12 male patients with dilated cardiomyopathy (DCM). Method: 10 normal subjects served as controls. 201-Thallium (201TI) and [123I]-phenyl-pentadecanoic acid (IPPA) were administered during bicycle exercise under fasting conditions.

Results: All patients showed non-homogeneous tracer uptake defects for 201TI and IPPA. k1 was significantly higher in DCM patients than controls. k1 showed significant inverse correlation between cardiac index, left-ventricular ejection fraction, left-ventricular enddiastolic pressure and echocardiographic left-ventricular ejection fraction.

Conclusion: We presume that an increased regional rate constant of IPPA influx into the myocardial tissue in patients with DCM reflects a compensatory mechanism of altered myocardium.

Key Words: Dilated cardiomyopathy • Fatty acid metabolism • Scintigraphy

Received July 10, 2001; Revised September 28, 2001; Accepted December 17, 2001


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