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European Journal of Heart Failure 2002 4(2):125-130; doi:10.1016/S1388-9842(01)00238-0
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© 2002 European Society of Cardiology

Influence of progressive renal dysfunction in chronic heart failure

A. Peter Maxwella, Hean Y. Ongb and D. Paul Nichollsb,*

a Regional Nephrology Unit Belfast City Hospital, Belfast, Northern Ireland, UK
b Department of Medicine, Royal Victoria Hospital Grosvenor Road, Belfast BT12 6BA, Northern Ireland, UK

* Corresponding author. Tel.: +44-28-9089-4951; fax: +44-28-9026-3168. E-mail address: dp.nicholls{at}royalhospitals.n-i.nhs.uk


  Abstract

Chronic heart failure (CHF) is often associated with impaired renal function due to hypoperfusion. Such patients are very sensitive to changes in renal perfusion pressure, and may develop acute tubular necrosis if the pressure falls too far. The situation is complicated by the use of diuretics, ACE inhibitors and spironolactone, all of which may affect renal function and potassium balance. Chronic renal failure (CRF) may also be associated with fluid overload. Anaemia and hypertension in CRF contribute to the development of left ventricular hypertrophy (LVH), which carries a poor prognosis, so correction of these factors is important.

Key Words: Chronic cardiac failure • Chronic renal failure

Received September 4, 2001; Revised October 24, 2001; Accepted October 29, 2001


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