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European Journal of Heart Failure 2001 3(5):627-630; doi:10.1016/S1388-9842(01)00159-3
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© 2001 European Society of Cardiology

Torsades de pointes caused by Mibefradil

Sven Gläser, Michaela Steinbach, Christian Opitz, Ullrich Wruck and Franz X. Kleber*

Unfallkrankenhaus Berlin, Department of Internal Medicine Warener Strasse 7, D-12683 Berlin, Germany

* Corresponding author. Tel.: +49-30-5681-3601; fax: +49-30-5681-3603. E-mail address: franz-xaverk{at}ukb.de (F.X. Kleber)


  Abstract

We report a case of symptomatic Torsades de pointes due to QTc prolongation by Mibefradil, which potentially explains unexpected deaths related to this drug. Multiple episodes of Torsades de pointes were documented in a 76-year-old woman with significant QTc prolongation of 0.53 s. After discontinuation of Mibefradil QTc intervals normalized and no further ventricular tachyarrythmias were observed. We conclude that Mibefradil can cause QTc prolongation and life threatening ventricular dysrhythmias.

Key Words: Mibefradil • Calcium channel blocker • Torsades de pointes • Ventricular tachycardias

Received February 2, 2001; Revised February 2, 2001; Accepted April 26, 2001


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