© 2001 European Society of Cardiology
Activation of the cardiac interleukin-6 system in advanced heart failure
a Department of Cardiothoracic Surgery, University of Muenster Albert-Schweitzer-Str. 33, D-48129 Muenster, Germany
b Department of Cardiology and Angiology, University of Muenster Albert-Schweitzer-Str. 33, D-48129 Muenster, Germany
c Institute for Arteriosclerosis Research, University of Muenster Domagkstr. 3, D-48149 Muenster, Germany
d Gerhard-Domagk-Institute of Pathology, University of Muenster Domagkstr. 17, D-48149 Muenster, Germany
e Institute for Clinical Chemistry and Laboratory Medicine, University of Muenster Albert-Schweitzer-Str. 33, D-48129 Muenster, Germany
f Department of Internal Medicine — Cardiology, University of Cologne Cologne, Germany
g Muenster University Transplant Center, Muenster University Muenster, Germany
h Columbia University, College of Physicians and Surgeons New York, NY, USA
* Corresponding author. Department of Cardiothoracic Surgery, University of Muenster, Albert-Schweitzer-Str. 33, D-48129 Muenster, Germany. Tel.: +49-251-835-6425; fax: +49-251-835-2998. E-mail address: plenz{at}uni-muenster.de (G. Plenz).
 |
Abstract |
|---|
Objectives: The study objective was to assess the cardiac expression of interleukin-6 (IL6) and its receptor (IL6R) in advanced heart failure.
Background: While IL6 plasma levels are elevated and associated with an impaired prognosis in advanced heart failure, little is known about the intracardiac expression of the IL6 system.
Methods: Heart tissue was obtained from 20 patients (n = 10, idiopathic dilated cardiomyopathy, age 44±15 years; n = 10, ischemic cardiomyopathy, age 55±8 years) at the time of transplantation. Left and right ventricular tissue was subjected to in situ hybridization, Northern blot analysis, and RT-PCR. Signals were quantified by densitometric scanning and corrected for G3PDH-mRNA levels. Right ventricular biopsy specimens (n = 11) of patients with arrhythmias and normal cardiac function served as controls. In addition, data were correlated with cardiac catheterization and echocardiography data obtained at transplant evaluation.
Results: Ventricular IL6 and IL6R transcripts were detected in all explant specimens examined. Expression of both mRNA species was higher than in controls (P = 0.001). Left ventricular IL6 mRNA levels correlated positively with heart rate (r = 0.77; P = 0.009), pulmonary capillary wedge pressure (r = 0.53; P = 0.03), right atrial pressure (r = 0.77; P = 0.003), and inversely with left ventricular ejection fraction (r = –0.61; P = 0.03). Right ventricular IL6 mRNA levels correlated inversely with cardiac index (r = –0.48; P = 0.05). IL6R expression did not correlate with hemodynamic data.
Conclusions: In advanced heart failure, cardiac IL6/IL6R mRNA expression is increased and may play a role in the pathophysiology of advanced heart failure.
Key Words: Interleukin-6 • Heart failure • Cardiomyopathy • Hemodynamics
Received December 5, 2000; Revised January 12, 2001; Accepted February 12, 2001
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  M. Sander, C. von Heymann, V. v. Dossow, C. Spaethe, W. F. Konertz, U. Jain, and C. D. Spies Increased interleukin-6 after cardiac surgery predicts infection. Anesth. Analg., June 1, 2006; 102(6): 1623 - 1629. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Avgeropoulou, I. Andreadou, S. Markantonis-Kyroudis, M. Demopoulou, P. Missovoulos, A. Androulakis, and I. Kallikazaros The Ca2+-sensitizer levosimendan improves oxidative damage, BNP and pro-inflammatory cytokine levels in patients with advanced decompensated heart failure in comparison to dobutamine Eur J Heart Fail, August 1, 2005; 7(5): 882 - 887. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M Vanderheyden, W J Paulus, M Voss, P Knuefermann, N Sivasubramanian, D Mann, and G Baumgarten Myocardial cytokine gene expression is higher in aortic stenosis than in idiopathic dilated cardiomyopathy Heart, July 1, 2005; 91(7): 926 - 931. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Bachetti, L. Comini, E. Pasini, and R. Ferrari Anti-cytokine therapy in chronic heart failure: new approaches and unmet promises Eur. Heart J. Suppl., November 1, 2004; 6(suppl_F): F16 - F21. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Gaertner, D. Lepailleur-Enouf, W. Gonzalez, A. Nicoletti, C. Mandet, M. Philippe, J.-J. Mercadier, and J.-B. Michel Pulmonary endothelium as a site of synthesis and storage of interleukin-6 in experimental congestive heart failure Eur J Heart Fail, August 1, 2003; 5(4): 435 - 442. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Yin, P. Li, M. Zheng, L. Chen, Q. Xu, K. Chen, Y.-y. Wang, Y.-y. Zhang, and C. Han Interleukin-6 Family of Cytokines Mediates Isoproterenol-induced Delayed STAT3 Activation in Mouse Heart J. Biol. Chem., May 30, 2003; 278(23): 21070 - 21075. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Jougasaki, H. Leskinen, A. M. Larsen, A. Cataliotti, H. H. Chen, and J. C. Burnett Jr. Leukemia inhibitory factor is augmented in the heart in experimental heart failure Eur J Heart Fail, March 1, 2003; 5(2): 137 - 145. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. C.H Ng, N. W Court, C. G dos Remedios, and M. A Bogoyevitch Activation of signal transducer and activator of transcription (STAT) pathways in failing human hearts Cardiovasc Res, February 1, 2003; 57(2): 333 - 346. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Sirera, A. Salvador, I. Roldan, R. Talens, A. Gonzalez-Molina, and M. Rivera Quantification of proinflammatory cytokines in the urine of congestive heart failure patients. Its relationship with plasma levels Eur J Heart Fail, January 1, 2003; 5(1): 27 - 31. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Plenz, H. Eschert, M. Erren, T. Wichter, M. Bohm, M. Flesch, H. H. Scheld, and M. C. Deng The interleukin-6/interleukin-6-receptorsystem is activated in donor hearts J. Am. Coll. Cardiol., May 1, 2002; 39(9): 1508 - 1512. [Abstract] [Full Text] [PDF]
|
|