Skip Navigation

European Journal of Heart Failure 2001 3(1):91-96; doi:10.1016/S1388-9842(00)00121-5
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (4)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Gadsbøll, N.
Right arrow Articles by Høilund-Carlsen, P. F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Gadsbøll, N.
Right arrow Articles by Høilund-Carlsen, P. F.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 2001 European Society of Cardiology

In-hospital heart failure, first-year ventricular dilatation and 10-year survival after acute myocardial infarction

Niels Gadsbøll*, Christian Torp-Pedersen and Poul Flemming Høilund-Carlsen

Department of Internal Medicine C and the Department of Clinical Physiology and Nuclear Medicine, Glostrup Hospital 2600 Glostrup, University of Copenhagen Denmark

* Corresponding author. Department of Cardiovascular Medicine, Bispebjerg Hospital, DK-2400 Copenhagen NV, Denmark. Tel.: +45-3531-3333; fax: +45-3531-3226. E-mail address: ng02{at}bbh.hosp.dk (N. Gadsbøll).


  Abstract

Background: Little is known about the factors that determine long-term prognosis in patients who have survived the first year after acute myocardial infarction (AMI).

Aims: To study the influence of left and right ventricular (LV and RV) dilatation during the first year after AMI on subsequent 10-year survival in comparison with in-hospital heart failure and other established prognostic indices.

Methods: Radionuclide ventriculography was performed before the era of thrombolysis and post-infarction ACE-inhibition in 57 patients with AMI at hospital discharge and again 1 year later, and compared with survival the ensuing 10 years.

Results: After 1 year significant LV-dilatation (> 20%) had occurred in 32 (56%) patients. One year after the re-investigation the mortality in these was 19% vs. 0% in patients without dilatation (P = 0.02); after 5 years the difference was 38 vs. 12% (P = 0.02), whereafter it declined and became insignificant at 10 years. Neither RV-dilatation, nor LVEF determined at discharge or at the 1-year reinvestigation influenced long-term survival. In contrast, clinical heart failure recorded during the hospital stay had a sustained negative influence on long-term survival.

Conclusion: Progressive LV dilatation after discharge and clinical heart failure during the hospital stay are both determinants of late survival after AMI, whereas LV ejection fraction at hospital discharge or 1 year later has little, if any, effect on survival beyond 1-year post-AMI.

Key Words: Myocardial infarction • Cardiac function • Prognosis

Received May 9, 2000; Accepted August 1, 2000


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.