Comparison of four right ventricular systolic echocardiographic parameters to predict adverse outcomes in chronic heart failure
1 Fédération de cardiologie, AP-HP, Groupe Henri-Mondor Albert-Chenevier, 51 Avenue Maréchal de Lattre de Tassigny, 94010 Créteil, France
2 Service de Physiologie–Explorations Fonctionnelles, AP-HP, Groupe Henri-Mondor Albert-Chenevier, Créteil, France
3 INSERM, Unité U955, Créteil F-94010, France
4 Université Paris 12, Faculté de Médecine, Créteil F-94010, France
5 Service de Pharmacologie Clinique and Unité, de Recherche Clinique, AP-HP, Groupe Henri-Mondor Albert-Chenevier, Créteil, France
6 Service de Chirurgie Cardio-thoracique, AP-HP, Groupe Henri-Mondor Albert-Chenevier, Créteil, France
* Corresponding author. Tel: 33 1 49 81 22 53, Fax: 33 1 49 81 42 24, Email: thibaud.damy{at}gmail.com
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Abstract |
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Aims: Heart failure (HF) has a poor prognosis. Several right ventricular (RV) echocardiographic parameters have been proposed as sensitive markers to detect patients at risk. Our objective was to compare the predictive value of four RV systolic echocardiographic parameters for outcomes in patients with HF.
Methods and results: One hundred and thirty-six patients with stable HF and a left ventricular ejection fraction <35% were assessed for the following: (i) RV fractional area (RVFA), (ii) tricuspid annular plane systolic excursion (TAPSE), (iii) integral of the systolic wave (ISWtdi), and (iv) peak systolic velocity (PSVtdi). ISWtdi and PSVtdi were measured using tissue Doppler imaging at the tricuspid annulus. The primary endpoint was death, urgent transplantation, urgent ventricular assist device implantation, or an acute HF episode. During a mean follow-up of 295 days, 33 patients reached the primary endpoint. The cut-off thresholds for RVFA, TAPSE, PSVtdi, and ISWtdi defined using receiver-operating characteristic curves were 36.8%, 13.5 mm, 9.5 cm s–1, and 1.75 cm, respectively. On Cox multivariate analysis, NYHA, log BNP, and only PSVtdi from the RV systolic parameters were found to be independent predictors of outcome.
Conclusion: PSVtdi is a strong independent predictor of outcome in HF at a threshold value of 9.5 cm s–1 and appears to be superior to other RV systolic echocardiographic parameters.
Key Words: Congestive heart failure • Right ventricle • Echocardiography
Received February 10, 2009; Revised July 20, 2009;
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  D. Farmakis, J. Parissis, and D. T. Kremastinos The prognostic role of echocardiographic indices in chronic heart failure: right ventricle revisited Eur J Heart Fail, December 1, 2009; 11(12): 1220 - 1220. [Full Text] [PDF]
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