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European Journal of Heart Failure Advance Access originally published online on July 3, 2009
European Journal of Heart Failure 2009 11(8):765-770; doi:10.1093/eurjhf/hfp091
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Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2009. For permissions please email: journals.permissions@oxfordjournals.org.

Endothelium-dependent and -independent vasodilation is more attenuated in ischaemic than in non-ischaemic heart failure

Magdalena Klosinska*, Tomasz Rudzinski, Piotr Grzelak, Ludomir Stefanczyk, Jaroslaw Drozdz and Maria Krzeminska-Pakula

Magdalena Klosinska, Medical University of Lodz, Lodz, Poland

* Corresponding author. Tel: +48 42 251 60 15, Fax: +48 42 251 60 15, Email: mklosinska{at}op.pl


  Abstract

Aims: Endothelial dysfunction in chronic heart failure (CHF) contributes to vasoconstriction. Underlying atherosclerosis may increase vascular abnormalities in ischaemic CHF. We aimed to compare flow-mediated dilation (FMD) and nitroglycerin-mediated dilation (NMD) of the brachial artery between patients with ischaemic and non-ischaemic CHF.

Methods and results: A total of 57 patients with systolic CHF participated in the study (mean age 59 ± 8 years, 81% male). Patients were in stable NYHA class II (40 patients, 70%) and III (17 patients, 30%). Ischaemic aetiology of CHF was confirmed by coronary angiography in 34 (60%) patients and ruled out in 23 (40%). Flow-mediated dilation and NMD of the brachial artery was assessed by high-resolution ultrasound. Endothelium-dependent vasodilation was markedly reduced in patients with ischaemic CHF compared with those with non-ischaemic aetiology of CHF—mean absolute change in artery diameter ({Delta}d) 0.09 ± 0.07 mm in ischaemic group vs. 0.18 ± 0.07 mm in non-ischaemic (P < 0.0001). Nitroglycerin-mediated vasodilation was also significantly different—{Delta}d = 0.14 ± 0.06 mm in ischaemic vs. 0.31 ± 0.10 mm in non-ischaemic CHF (P < 0.0001).

Conclusion: Endothelium-dependent and -independent vascular response is more attenuated in ischaemic than in non-ischaemic CHF.

Key Words: Heart failure • Endothelium • Atherosclerosis • Vasodilation

Received December 15, 2008; Revised April 21, 2009; Accepted April 29, 2009


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