Skip Navigation


European Journal of Heart Failure Advance Access originally published online on April 21, 2009
European Journal of Heart Failure 2009 11(6):573-580; doi:10.1093/eurjhf/hfp050
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
11/6/573    most recent
hfp050v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Choi, E.-Y.
Right arrow Articles by Chung, N.
PubMed
Right arrow PubMed Citation
Right arrow Articles by Choi, E.-Y.
Right arrow Articles by Chung, N.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2009. For permissions please email: journals.permissions@oxfordjournals.org.

Patterns of late gadolinium enhancement are associated with ventricular stiffness in patients with advanced non-ischaemic dilated cardiomyopathy{dagger}

Eui-Young Choi1, Byoung Wook Choi2,*, Sung-Ai Kim1, Sang Jae Rhee1, Chi Young Shim1, Young Jin Kim2, Seok-Min Kang1, Jong-Won Ha1 and Namsik Chung1,*

1 Cardiology Division, Yonsei Cardiovascular Center and Cardiovascular Research Institute, Shinchon-dong 134, Seoul, South Korea 120-752
2 Department of Radiology, Yonsei University College of Medicine, Seoul, Republic of Korea

* Corresponding author. Tel: +82 2 2228 2381, Fax: +82 2 2227 7943, Email: bchoi{at}yuhs.ac (B.W.C.) or Tel: +82 2 2228 8460, Fax: +82 2 2227 7943, Email: namsikc{at}yuhs.ac (N.C.)


  Abstract

Aims: Despite the prognostic importance of ventricular filling and ventricular–arterial interaction in patients with advanced systolic heart failure, the structural determinants of these parameters have not been fully studied. We aimed to investigate whether patterns of late gadolinium enhancement (LGE) on cardiac magnetic resonance affect ventricular elastic properties or performance in patients with non-ischaemic dilated cardiomyopathy (DCM).

Methods and results: Patients (n = 49) with markedly reduced systolic function (left ventricular (LV) ejection fraction <35%) due to longstanding non-ischaemic DCM underwent contrast-enhanced cardiac magnetic resonance after comprehensive echo-Doppler evaluations. The single beat-derived end-diastolic elastance, end-systolic elastance, arterial elastance, and dyssynchrony indices were measured by echo. On the basis of LGE patterns, patients could be divided into three groups: non-LGE (n = 18), non-midwall LGE (n = 13), and midwall LGE (n = 18). The midwall LGE group had lower LV systolic longitudinal velocity (4.6 ± 1.7 for non-LGE vs. 4.3 ± 1.2 for non-midwall LGE vs. 3.5 ± 1.0 cm/s for midwall LGE, P = 0.025), higher end-diastolic elastance index (0.41 ± 0.21 vs. 0.46 ± 0.31 vs. 0.85 ± 0.51 respectively, P = 0.008), and a more impaired ventriculoarterial coupling index (3.14 ± 1.53 vs. 2.88 ± 1.94 vs. 5.52 ± 3.18, P = 0.006) than other subgroups.

Conclusion: Patients with midwall LGE had a higher ventricular stiffness index and more impaired ventriculoarterial coupling when compared with other non-ischaemic DCM patients.

Key Words: dilated cardiomyopathy • ventricular elastance • magnetic resonance imaging

Received October 18, 2008; Revised February 13, 2009; Accepted February 26, 2009

{dagger} This study was presented in part at Annual Scientific Session of the American Heart Association, held in November 2007 at Orlando, FL, USA.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.