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European Journal of Heart Failure 2009 11(2):147-153; doi:10.1093/eurjhf/hfn017
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Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2009. For permissions please email: journals.permissions@oxfordjournals.org.

Transplantation of mesenchymal stem cells within a poly(lactide-co-{varepsilon}-caprolactone) scaffold improves cardiac function in a rat myocardial infarction model

Jiyong Jin1,2, Sung In Jeong3, Young Min Shin4, Kwang Suk Lim4, Heung soo Shin4, Young Moo Lee3, Hyun Chul Koh5 and Kyung-Soo Kim1,6,*

1 Division of Cardiology, College of Medicine, Hanyang University, 17 Haengdang-dong, Seongdong-ku, Seoul 133-791, South Korea
2 Department of Cardiology, Yanbian University Hospital, Yanji, China
3 School of Chemical Engineering, College of engineering, Hanyang University, Seoul, Korea
4 Department of Bioengineering, Hanyang University, Seoul, Korea
5 Department of pharmacology, College of Medicine, Hanyang University, Seoul, Korea
6 Department of Biomedical Science, Hanyang University, Seoul, Korea

* Corresponding author. Tel: +82 2 2290 8312, Fax: +82 2 2298 9183, Email: kskim{at}hanyang.ac.kr


  Abstract

Aims: Cardiac tissue engineering has been proposed as an appropriate method to repair myocardial infarction (MI). Evidence suggests that a cell with scaffold combination was more effective than a cell-only implant. Nevertheless, to date, there has been no research into elastic biodegradable poly(lactide-co-{epsilon}-caprolactone) (PLCL) scaffolds. The aim of this study was to investigate the effect of mesenchymal stem cells (MSCs) with elastic biodegradable PLCL scaffold transplants in a rat MI model.

Methods and results: Ten days after inducing MI through the cryoinjury method, a saline control, MSC, PLCL scaffold, or MSC-seeded PLCL scaffold was transplanted onto the hearts. Four weeks after transplantation, cardiac function and histology were evaluated. Transplanted MSCs survived and differentiated into cardiomyocytes in the injured region. Left ventricular ejection fraction in the MSC + PLCL group increased by 23% compared with that in the saline group; it was also higher in the MSC group. The infarct area in the MSC + PLCL group was decreased by 29% compared with that in the saline group; it was also reduced in the MSC group.

Conclusion: Mesenchymal stem cells plus PLCL should be an excellent combination for cardiac tissue engineering.

Key Words: Myocardial infarction • Heart failure • Mesenchymal stem cell • Poly(lactide-co-{epsilon}-caprolactone) • Cardiac tissue engineering • Scaffold

Received August 5, 2008; Revised August 25, 2008; Accepted November 3, 2008


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