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European Journal of Heart Failure 2009 11(12):1214-1219; doi:10.1093/eurjhf/hfp162
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Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2009. For permissions please email: journals.permissions@oxfordjournals.org.

Clinical trials update from the European Society of Cardiology Meeting 2009: AAA, RELY, PROTECT, ACTIVE-I, European CRT survey, German pre-SCD II registry, and MADIT-CRT

John G.F. Cleland, Alison P. Coletta*, Ashraf Yassin, Laszlo Buga, Azam Torabi and Andrew L. Clark

Department of Cardiology, Hull York Medical School, University of Hull, Castle Hill Hospital, Cottingham, Kingston-upon-Hull HU16 5JQ, UK

* Corresponding author. Tel: +44 1482 461777, Fax: +44 1482 461779, Email: a.p.coletta{at}hull.ac.uk


  Abstract

This article provides information and a commentary on trials relevant to the pathophysiology, prevention, and treatment of heart failure presented at the annual meeting of the European Society of Cardiology held in Barcelona in 2009. The AAA study does not support the routine use of aspirin for the prevention of vascular events in patients with asymptomatic atherosclerosis. RELY suggests that dabigatran may be more effective than warfarin for the prevention of stroke in patients with atrial fibrillation. Rolofylline was not superior to placebo in improving outcomes in patients with acute heart failure enrolled in the PROTECT study, but dyspnoea was improved. Data from ACTIVE-I suggest that irbesartan does not provide additional therapeutic benefit in patients with atrial fibrillation who are well controlled on current therapy. The European cardiac resynchronization therapy (CRT) survey provides interesting epidemiological data on current CRT device usage. The German pre-SCD II registry identified a low prevalence of patients with a reduced ejection fraction following myocardial infarction. Implantation of CRT-D rather than an implantable cardioverter defibrillator in patients with mild heart failure and QRS ≥130 ms reduced the risk of hospitalization for heart failure in MADIT-CRT; mortality was similarly low with each device.

Key Words: Randomized controlled trials • Heart failure

Received October 22, 2009; Revised October 27, 2009;
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