European Journal of Heart Failure Advance Access originally published online on October 8, 2009
European Journal of Heart Failure 2009 11(11):1057-1062; doi:10.1093/eurjhf/hfp128
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Serum levels of large tenascin-C variants, matrix metalloproteinase-9, and tissue inhibitors of matrix metalloproteinases in concentric versus eccentric left ventricular hypertrophy
1 Department of Internal Medicine I/Cardiology, University Hospital of Jena, Erlanger Allee 101, 07740 Jena, Germany
2 Institute of Pathology, University Hospital of Jena, Ziegelmühlenweg 1, 07743 Jena, Germany
3 Department of General, Visceral, and Vascular Surgery, University Hospital Jena, 07740 Jena, Germany
* Corresponding author. Tel: +49 3641 9324127, Fax: +49 3641 9324102, Email: marcus.franz{at}med.uni-jena.de
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Abstract |
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Aims: Chronic hypertension may cause left ventricular hypertrophy (LVH). The role of matrix metalloproteinases (MMPs), tissue inhibitors of matrix metalloproteinases (TIMPs), and tenascin-C (Tn-C) splice variants in concentric vs. eccentric left ventricular remodelling has not been investigated.
Methods and results: Serum levels of B or C domain containing Tn-C, MMP-9, TIMP-1, -2, and -4 were determined in concentric (left ventricular posterior wall thickness >13 mm and intraventricular septum >13 mm, n = 61) and eccentric (end-diastolic left ventricular diameter >55 mm or end-systolic left ventricular diameter >40 mm, n = 34) LVH by enzyme-linked immunoassays. Levels of B domain containing Tn-C were higher in patients with LVH than in normal volunteers (P = 0.020) and higher in eccentric LVH (EH) compared with concentric LVH (CH) (P = 0.003). A cut-off value of 900 ng/mL might discriminate between these different forms of LVH. Matrix metalloproteinase-9 was higher in patients with LVH than in normal volunteers (P = 0.042), and levels were decreased in EH compared with CH (P = 0.028). Patients with LVH had higher levels of TIMP-1 (P = 0.059), TIMP-2 (P = 0.043), and TIMP-4 (P = 0.163) than normal volunteers, but there were no differences between the LVH groups.
Conclusion: Our data suggest that myocardial remodelling in LVH is associated with changes in serum levels of MMP-9, TIMP-1, -2, -4, and Tn-C splice variants. In addition, B domain containing Tn-C discriminated EH from CH and might be suggested as a potential diagnostic marker.
Key Words: Tenascin-C • MMP-9 • TIMP • Hypertension • Left ventricular hypertrophy
Received May 23, 2009; Revised August 13, 2009; Accepted August 21, 2009