Skip Navigation

European Journal of Heart Failure 2009 11(10):952-957; doi:10.1093/eurjhf/hfp122
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Ghio, S.
Right arrow Articles by Visconti, L. O.
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ghio, S.
Right arrow Articles by Visconti, L. O.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2009. For permissions please email: journals.permissions@oxfordjournals.org.

Regional abnormalities of myocardial deformation in patients with hypertrophic cardiomyopathy: correlations with delayed enhancement in cardiac magnetic resonance

Stefano Ghio1,*, Miriam Revera1, Francesca Mori1, Catherine Klersy2, Arturo Raisaro1, Claudia Raineri1, Alessandra Serio3, Michele Pasotti3 and Luigi Oltrona Visconti1

1 Division of Cardiology, Fondazione IRCCS Policlinico S. Matteo, Piazza Golgi 1, Pavia 27100, Italy
2 Clinical Epidemiology and Biometry Service, Fondazione IRCCS Policlinico S. Matteo, Pavia, Italy
3 Centre for Inherited Cardiovascular Diseases, Fondazione IRCCS Policlinico S. Matteo, Pavia, Italy

* Corresponding author. Tel: +39 0382 503713, Fax: +39 0382 503159, Email: s.ghio{at}smatteo.pv.it


  Abstract

Aims: Hypertrophic cardiomyopathy (HCM) is a genetic disease histologically characterized by a profound disarray of myocardial fibres and by local fibrosis. We sought to characterize regional left ventricular contractility in HCM patients using deformation analysis and to compare it with the presence or absence of delayed enhancement in cardiac magnetic resonance (CMR).

Methods and results: We studied 58 HCM patients (mean age 41 years, 37 male). The control population comprised 15 normal subjects. Colour tissue-Doppler imaging was acquired in two-dimensional mode from apical four-chamber and two-chamber views; off-line analysis was performed in four basal and four middle left ventricular segments. Gadolinium-enhanced CMR was performed in 36 HCM patients. In HCM patients, peak systolic strain was not uniform across left ventricular segments; differences were not related to site or thickness of the segment analysed. Paradoxically, positive systolic strain values were measured in six middle segments. Delayed CMR enhancement was associated with lower peak systolic strain (P = 0.007). Regional non-uniformities in peak systolic strain were not observed in normal subjects.

Conclusion: Areas of reduced left ventricular contractility in deformation analysis are associated with delayed CMR enhancement in patients with HCM.

Key Words: Hypertrophic cardiomyopathy • Tissue-Doppler imaging • Systolic deformation • Cardiac magnetic resonance

Received December 28, 2008; Revised June 9, 2009; Accepted August 7, 2009


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.