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European Journal of Heart Failure 2008 10(8):733-739; doi:10.1016/j.ejheart.2008.06.007
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© 2008 European Society of Cardiology

Interleukin-10 improves left ventricular function in rats with heart failure subsequent to myocardial infarction

Christian Stumpf*, Katrin Seybold, Sebastian Petzi, Gerald Wasmeier, Dorette Raaz, Atilla Yilmaz, Thomas Anger, Werner G. Daniel and Christoph D. Garlichs

Department of Cardiology, University of Erlangen-Nuremberg Erlangen, Germany

* Corresponding author. Department of Cardiology/Medical Clinic II, University of Erlangen-Nuremberg, Ulmenweg 18, 91054 Erlangen, Germany. Tel.: +49 91 31 853 5000; fax: +49 1212 5 107 908 84. E-mail address: ch.stumpf{at}web.de (C. Stumpf).


  Abstract

Evidence has shown that pro-inflammatory cytokines, especially TNF-{alpha}, are involved in the inflammatory response in the remodelling process after myocardial infarction (MI). Although IL-10, an anti-inflammatory cytokine, has been shown to antagonize some of the deleterious effects of TNF-{alpha}, little is known about its role in post-MI left ventricular (LV) dysfunction. The aim of the present study was to investigate whether a therapy with rhIL-10 could be beneficial in an animal model of post-MI heart failure (HF).

Rats with experimental MI were treated with rhIL-10 (75 mn;g/kg/d sc) starting directly after MI induction, and continuing for 4 weeks. Controls were untreated MI and sham-operated rats. Cardiac function was assessed by echocardiography and cardiac catheterization 4 weeks after MI induction. Membrane-bound and soluble fractions of TNF-{alpha}, IL-6 and IL-10, the ratio of TNF-{alpha} to IL-10, serum levels of MCP-1 as well as myocardial macrophage infiltration, were analyzed. Treatment with rhIL-10 significantly improved post-MI LV function (FS +127%;, dP/dtmax +131%; LVEDP–36%). This effect was associated with a significant decrease in pro-inflammatory cytokine and chemokine levels (TNF-{alpha}, IL-6, MCP-1) and furthermore resulted in a reduced myocardial infiltration of macrophages.

Key Words: Interleukin-10 • Myocardial infarction • Heart failure • Inflammation

Received May 18, 2008; Accepted June 12, 2008


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