Effect of repeated intracoronary injection of bone marrow cells in patients with ischaemic heart failure The Danish Stem Cell study--Congestive Heart Failure trial (DanCell-CHF)

doi:10.1016/j.ejheart.2008.05.010

European Journal of Heart Failure 2008 10(7):661-667; doi:10.1016/j.ejheart.2008.05.010

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Effect of repeated intracoronary injection of bone marrow cells in patients with ischaemic heart failure The Danish Stem Cell study—Congestive Heart Failure trial (DanCell-CHF)

Axel C.P. Diederichsen^a^,*, Jacob E. Møller^a, Per Thayssen^a, Anders B. Junker^a, Lars Videbæk^a, Susanne G. Sækmose^b, Torben Barington^b, Malthe Kristiansen^c and Moustapha Kassem^c

^a Department of Cardiology, Odense University Hospital Denmark
^b Department of Clinical Immunology, Odense University Hospital Denmark
^c Department of Endocrinology and Metabolism, Odense University Hospital Denmark

^* Corresponding author. Department of Cardiology, Sdr. Boulevard 29, Odense University Hospital, DK-5000 Odense C, Denmark. Tel.: +45 65412627; fax: +45 63120854. E-mail address: a.diederichsen{at}dadlnet.dk (A.C.P. Diederichsen).

Abstract

Background: It has been suggested that myocardial regeneration may be achievedby a single intracoronary bone marrow derived stem cell infusionin selected patients with ischaemic heart disease. The effectis uncertain in patients with chronic ischaemic heart failureand it is not known whether repeated infusions would have additionalpositive effects.

Aims: To assess whether two treatments of intracoronary infusion ofbone marrow stem cells, administered 4 months apart, could improveleft ventricular (LV) systolic function in patients with chronicischaemic heart failure.

Methods: The study was prospective and non-randomised, comprising anobservational baseline period of 4 months followed by an interventionalperiod of 12 months. Intracoronary bone marrow cell infusionwas performed at the end of the baseline period and repeated4 months later.

Results: 32 patients were included. LV ejection fraction remained unchanged(33±9% vs. 34±10% after 8 months, p=0.30). Likewise,there was no significant change in LV end-systolic volume, wallmotion score index (WMSI) or contractile reserve. At 12 months,a decrease in target vessel WMSI was seen (2.17±0.34vs. 2.06±0.46, p=0.02). Furthermore, NYHA class improved(p<0.0001). No deaths were observed.

Conclusion: In this non-randomised study, no change in LV ejection fractioncould be demonstrated after repeated intracoronary bone marrowstem cell treatment in patients with chronic ischaemic heartfailure.

Key Words: Ischaemic heart failure • Stem cell therapy • Left ventricular ejection fraction

Received January 30, 2008; Revised April 7, 2008; Accepted May 15, 2008

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