© 2008 European Society of Cardiology
Serum uric acid correlates with extracellular superoxide dismutase activity in patients with chronic heart failure
a Centro FONDAP Estudios Moleculares de la Célula, Universidad de Chile Santiago, Chile
b Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile Santiago, Chile
c Instituto de Ciencias Biomédicas, Facultad de Medicina, Universidad de Chile Santiago, Chile
d Facultad de Medicina, Pontificia Universidad Católica de Chile Chile
* Corresponding authors. Pablo is to be contacted at Facultad de Medicina, Pontificia Universidad Católica de Chile, Marcoleta 367, Santiago, Chile. Lavandero, Centro FONDAP CEMC, Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile, Olivos 1007, Santiago 8380492, Chile. E-mail addresses: pcastro{at}med.puc.cl (P. Castro), slavander{at}uchile.cllavander{at}vtr.net (S. Lavandero)
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Abstract |
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Increased serum uric acid has been identified as an independent risk factor for cardiovascular disease. However, because of its antioxidant capacity, uric acid may play a beneficial role in endothelial function. This paradoxical relationship between uric acid and endothelial function in chronic heart failure patients remains poorly understood. Thirty-eight chronic heart failure patients (New York Heart Association functional class II–III, mean age 58±10 years and mean left ventricular ejection fraction 25±8%) and twelve age-and-sex-matched healthy controls were studied. Chronic heart failure patients showed higher uric acid levels (7.3±2.3 mg/dL vs. 6.1±0.2 mg/dL, p<0.05) and lower extracellular superoxide dismutase activity (136±36 U ml–1 min–1 vs. 203±61 U ml–1 min–1, p<0.01) and endothelium-dependent vasodilatation (4.0±1.6% v. 9.1±3.0%, p<0.01) when compared with control subjects. In chronic heart failure patients, correlations between both uric acid levels and extracellular superoxide dismutase activity (r=0.45; p<0.01), and uric acid and endothelium-dependent vasodilatation (r=0.35; p=0.03) were detected. These correlations were not observed in healthy individuals, suggesting a positive effect of uric acid on endothelial function partially mediated by modulation of extracellular superoxide dismutase activity in chronic heart failure.
Key Words: Extracellular superoxide dismutase • Uric acid • Endothelial function • Chronic heart failure • Oxidative stress
Received October 29, 2007; Revised April 25, 2008; Accepted May 19, 2008
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