© 2008 European Society of Cardiology
Beneficial effects of bisoprolol on the survival of hypertensive diastolic heart failure model rats
a Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine Suita, Japan
b Genome Information Research Center, Osaka University Suita, Japan
c Cardiovascular Division, Department of Internal Medicine, Hyogo College of Medicine Nishinomiya, Japan
d Department of Radiological Sciences, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama Toyama, Japan
e The Center for Advanced Medical Engineering and Informatics, Osaka University Suita, Japan
* Corresponding author. Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita 565-0871, Japan. Tel.: +81 6 6879 6612; fax: +81 6 6879 6613. E-mail address: kazuhiro{at}medone.med.osaka-u.ac.jp (K. Yamamoto).
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Abstract |
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Background: β-blocker therapy is an established therapeutic strategy for systolic heart failure. However, its benefits in diastolic heart failure (DHF) are controversial.
Aims: This study was designed to investigate the effects of bisoprolol on DHF.
Methods and results: Dahl salt-sensitive rats fed on 8% NaCl diet from age 6weeks, DHF model rats, were divided into three groups at age 13 weeks. One group was treated with bisoprolol 12.5 mg/kg/day (Low dose group, n=18), one group was treated with bisoprolol 250 mg/kg/day (High dose group, n=18), and there was also an untreated group (Untreated group, n=18). The survival rate was best in the High dose group. Left ventricular hypertrophy and the expression of proinflammatory cytokines in the myocardium were significantly attenuated in the High dose group, but not in the Low dose group, and oxidative stress was most suppressed in the High dose group. Measurement with electron spin resonance revealed that bisoprolol had a potent scavenging ability, and bisoprolol attenuated the down-regulation of peroxisome proliferation-activated receptor coactivator-1
, an important element in the mitochondrial reactive oxygen species detoxification system.
Conclusion: β-blocker administration, particularly at high dose, improved the survival rate of the DHF model, at least partly through the attenuation of inflammatory changes and oxidative stress.
Key Words: Diastole • Heart failure • β-blocker • Inflammation • Oxidative stress
Received August 29, 2007; Revised December 24, 2007; Accepted March 4, 2008
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