Skip Navigation

European Journal of Heart Failure 2008 10(12):1177-1180; doi:10.1016/j.ejheart.2008.08.008
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Prasad, S. K.
Right arrow Articles by Petrou, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Prasad, S. K.
Right arrow Articles by Petrou, M.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 2008 European Society of Cardiology

Gene expression profiling of human hibernating myocardium: Increased expression of B-type natriuretic peptide and proenkephalin in hypocontractile vs normally-contracting regions of the heart

Sanjay K. Prasada,b, Angela Clerka, Timothy E. Cullingforda, Alexander W.Y. Chena, Timothy J. Kempa, Timothy M. Cannellb, Martin R. Cowiea,* and Mario Petrouc

a NHLI Division, Faculty of Medicine, Imperial College London London, UK
b Cardiovascular Magnetic Resonance Unit, Royal Brompton and Harefield NHS Trust London, UK
c Department of Cardiac Surgery, Royal Brompton and Harefield NHS Trust London, UK

* Corresponding author. NHLI Division, Faculty of Medicine, Imperial College London, Dovehouse Street, London SW3 6LY, UK. Tel.: +44 20 7351 8856/8164; fax: +44 20 7351 8148. E-mail address: m.cowie{at}imperial.ac.uk (M.R. Cowie).


  Abstract

A greater understanding of the molecular basis of hibernating myocardium may assist in identifying those patients who would most benefit from revascularization. Paired heart biopsies were taken from hypocontractile and normally-contracting myocardium (identified by cardiovascular magnetic resonance) from 6 patients with chronic stable angina scheduled for bypass grafting. Gene expression profiles of hypocontractile and normally-contracting samples were compared using Affymetrix microarrays. The data for patients with confirmed hibernating myocardium were analysed separately and a different, though overlapping, set (up to 380) of genes was identified which may constitute a molecular fingerprint for hibernating myocardium. The expression of B-type natriuretic peptide (BNP) was increased in hypocontractile relative to normally-contracting myocardium. The expression of BNP correlated most closely with the expression of proenkephalin and follistatin 3, which may constitute additional heart failure markers. Our data illustrate differential gene expression in hypocontractile and/hibernating myocardium relative to normally-contracting myocardium within individual human hearts. Changes in expression of these genes, including increased relative expression of natriuretic and other factors, may constitute a molecular signature for hypocontractile and/or hibernating myocardium.

Key Words: Genes • Hibernation • Myocardium • Natriuretic peptides

Received December 10, 2007; Revised May 1, 2008; Accepted August 14, 2008


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.